| Immunogen | PurifiedrecombinanthumanMARCKS;Epitopemappedtothecarboxyl-terminal. |
| Clone | 2F12 |
| Host | Mouse |
| Specificity | MARCKS |
| Isotype | IgG1 |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneisasubstrateforproteinkinaseC.Itislocalizedtotheplasmamembraneandisanactinfilamentcrosslinkingprotein.PhosphorylationbyproteinkinaseCorbindingtocalcium-calmodulininhibitsitsassociationwithactinandwiththeplasmamembrane,leADIngtoitspresenceinthecytoplasm.Theproteinisthoughttobeinvolvedincellmotility,phagocytosis,membranetraffickingandmitogenesis. |
| GeneSymbol | - MARCKS
- 80K-L
- MACS
- PRKCSL
- FLJ14368
- phosphomyristin
- MRACKS
- PKCSL
- FLJ90045
|
| PurificationMethod | Ascites |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P29966#MARCKSisthemostprominentcellularsubstrateforproteinkinaseC.Thisproteinbindscalmodulin,actin,andsynapsin.MARCKSisafilamentous(F)actincross-linkingprotein. SIZE:332aminoacids;31555Da PTM:PhosphorylationbyPKCdisplacesMARCKSfromthemembrane.ItalsoinhibitstheF-actincross-linkingactivity. SIMILARITY:SwissProt:P29966##BelongstotheMARCKSfamily. |
| MolecularWeight | nonegiven |