| Immunogen | N-terminal6His-taggedrecombinantfulllengthhumanGSK3β. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | GSK3alphaandbeta. |
| Isotype | IgG |
| SpeciesReactivity | |
| SpeciesReactivityNote | Humanandmouse. Predictedtocross-reactwithratbasedonsequencehomology. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase, homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolof severalregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscription factors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001) |
| GeneSymbol | |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUNBysimilarity. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. SUBUNITSTRUCTURE:MonomerBysimilarity. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily. Contains1proteinkinasedomain.
|
| MolecularWeight | ~46kDa(beta)and51kDa(alpha) |