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    當前位置 ： Millipore >>> Millipore/04-775 | Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal/04-775/100 µL
    Millipore/04-775 | Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal/04-775/100 µL
    • Millipore/04-775 | Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal/04-775/100 µL

    Millipore/04-775 | Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal/04-775/100 µL

    價格: ￥3444.00 市場價: 5740.00
    打印產品信息
    貨號: 04-775
    品牌: Millipore
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      • Description
        CatalogueNumber04-775
        Replaces05-775
        DescriptionAnti-Ha-RasAntibody,cloneMC57,rabbitmonoclonal
        AlternateNames
        • GTP-andGDP-bindingpeptideB
        • GTPaseHRas
        • Ha-Ras1proto-oncoprotein
        • RasfamilysmallGTPbindingproteinH-Ras
        • Transformingproteinp21
        • c-has/basp21protein
        • c-ras-Ki-2activatedoncogene
        • p19H-RasIDXprotein
        • transformationgene:oncogeneHAMSV
        • v-Ha-rasHarveyratsarcomaviraloncogenehomolog
        BackgroundInformationRasproteinsaresmallGTP-bindingproteinswhich,unliketheheterotrimericG-proteins,containallGTPaseandeffectorfunctionswithinasinglepolypeptide.AtleastthreeisoformsofRasexist,Ki-Ras,Ha-RasandN-Ras,withdistinctexpressionpatternsbutsimilarsignalingactivity.Rasispalmitoylatedandfarnesylatedatthecarboxyterminus,anchoringitinthemembrane.Inrestingcells,RasisloadedwithGDP,andisactivatedsubsequenttogrowthfactorstimulationofreceptors,whichrecruitRasGuaninenucleotideExchangeFactorstotheplaneofthemembrane.ProximityofexchangefactorstotheRasproteinscausesreleaseofGDP,anditsreplacementbyGTP.InitsGTP-boundform,Rasbindsseveralproteins,includingRaf,RalGDSandPI3Kinase.InactivationofRasoccursbyGTPhydrolysis,whichisgreatlyacceleratedbyRasGAPorNF-1,twoknownRasGTPaseActivatingProteins.ItispossIBLetoassayforRasactivationbyincubationoflysateswiththeRas-bindingdomainofRaf-1,whichselectivelybindstoRas:GTP.
        ProductInformation
        FormatCultureSupernatant
        Control
        • IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431lysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
        PresentationCulturedsupernantantcontaining0.05%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Applications
        ApplicationDetectHa-RasusingthisAnti-Ha-RasAntibody,cloneMC57validatedforuseinWB.
        KeyApplications
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenGSTfusionproteincorrespondingtofulllengthhumanHa-Ras.CloneMC57.
        CloneMC57
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostRabbit
        SpecificityRecognizesHa-Ras,Mr~21kDa.DoesnotcrossreactwithCdc42,RhoorRac1.
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Mouse
        • Rat
        SpeciesReactivityNoteHuman.Predictedtocross-reactwithmouseandratbasedonsequencehomology.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgenebelongstotheRasoncogenefamily,whosemembersarerelatedtothetransforminggenesofmammaliansarcomaretroviruses.Theproductsencodedbythesegenesfunctioninsignaltransductionpathways.TheseproteinscanbindGTPandGDP,andtheyhaveintrinsicGTPaseactivity.Thisproteinundergoesacontinuouscycleofde-andre-palmitoylation,whichregulatesitsrapidexchangebetweentheplasmamembraneandtheGolgiapparatus.MutationsinthisgenecauseCostellosyndrome,adisease
        characterizedbyincreasedgrowthattheprenatalstage,growthdeficiencyatthepostnatalstage,predispositiontotumorformation,mentalretardation,skinandmusculoskeletalabnormalities,distinctivefacialappearanceandcardiovascularabnormalities.Defectsinthisgeneareimplicatedinavarietyofcancers,includingbladdercancer,follicularthyroidcancer,andoralsquamouscellcarcinoma.Multipletranscriptvariants,whichencodedifferentisoforms,havebeenidentifiedforthisgene.
        GeneSymbol
        • C-BAS/HAS
        • C-H-RAS
        • C-HA-RAS1
        • CTLO
        • H-RASIDX
        • H-Ras-1
        • HAMSV
        • HRAS1
        • Ha-Ras
        • K-RAS
        • N-RAS
        • OTTHUMP00000162769
        • OTTHUMP00000166053
        • OTTHUMP00000166055
        • RASH1
        • c-H-ras
        • p21ras
        UniProtNumber
        UniProtSummaryFUNCTION:RasproteinsbindGDP/GTPandpossessintrinsicGTPaseactivity.Ref.18Ref.32
        ENZYMEREGULATION:AlternatebetweenaninactiveformboundtoGDPandanactiveformboundtoGTP.Activatedbyaguaninenucleotide-exchangefactor(GEF)andinactivatedbyaGTPase-activatingprotein(GAP).
        SUBUNITSTRUCTURE:InitsGTP-boundforminteractswithPLCE1.InteractswithTBC1D10C.InteractswithRGL3Bysimilarity.FormsasignalingcomplexwithRASGRP1andDGKZ.InteractswithRASSF5.
        SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside.Golgiapparatusmembrane;Lipid-anchor.Note:ShuttlesbetweentheplasmamembraneandtheGolgiapparatus.
        PTM:PalmitoylatedbytheZDHHC9-GOLGA7complex.Acontinuouscycleofde-andre-palmitoylationregulatesrapidexchangebetweenplasmamembraneandGolgi.S-nitrosylated;criticalforredoxregulation.Importantforstimulatingguaninenucleotideexchange.Nostructuralperturbationonnitrosylation.
        INVOLVEMENTINDISEASE:DefectsinHRASarethecauseofCostellosyndrome[MIM:218040];alsoknownasfaciocutaneoskeletalsyndrome.Costellosyndromeisarareconditioncharacterizedbyprenatallyincreasedgrowth,postnatalgrowthdeficiency,mentalretardation,distinctivefacialappearance,cardiovascularabnormalities(typicallypulmonicstenosis,hypertrophiccardiomyopathyand/oratrialtachycardia),tumorpredisposition,skinandmusculoskeletalabnormalities.
        DefectsinHRASarethecauseofcongenitalmyopathywithexcessofmusclespindles(CMEMS)[MIM:218040].CMEMSisavariantofCostellosyndrome.
        DefectsinHRASmaybeacauseofsusceptibilitytoHurthlecellthyroidcarcinoma[MIM:607464];alsoknownasHurthlecellthyroidneoplasia.Hurthlecellthyroidcarcinomaaccountsforapproximately3%ofallthyroidcancers.Althoughtheyareclassifiedasvariantsoffollicularneoplasms,theyaremoreoftenmultifocalandsomewhatmoreaggressiveandarelesslikelytotakeupiodinethanareotherfollicularneoplasms.Mutationswhichchangepositions12,13or61activatethepotentialofHRAStotransformculturedcellsandareimplicatedinavarietyofhumantumors.DefectsinHRASareacauseofbladdercancer.DefectsinHRASarethecauseoforalsquamouscellcarcinoma(OSCC).
        SEQUENCESIMILARITIES:BelongstothesmallGTPasesuperfamily.Rasfamily.
        MASSSPECTROMETRY:Molecularmassis6.223±2Dafrompositions112-166.DeterminedbyESI.Molecularmassis6.253±2Dafrompositions112-166.DeterminedbyESI.Includesonenitricoxidemolecule.
        MolecularWeight~21kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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