| Immunogen | AsyntheticpeptidecorrespondingtoN-terminusofhumanCaspase-2p15subunit.Theantibodyshouldrecognizebothpro-form(~50kDa)andp15cleaved-formofCaspase-2. | 
| Clone | Y61 | 
| Host | Rabbit | 
| Specificity | RecognizesHuman,MouseCaspase-2. | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Human,Mouse(positivecontrol:Jurkatcelllysate) | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theproteolyticcleavageofthisproteinisinducedbyavarietyofapoptoticstimuli.Alternativesplicingofthisgeneresultsinmultipletranscriptvariantsthatencodedifferentisoforms. | 
| GeneSymbol | - CASP2
 - NEDD2
 - ICH1
 - ICH-1L/1S
 - ICH-1L
 - NEDD-2
 - CASP-2
 
  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P42575#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Mightfunctionbyeitheractivatingsomeproteinsrequiredforcelldeathorinactivatingproteinsnecessaryforcellsurvival. SIZE:452aminoacids;50685Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbyap18subunitandap12subunit.InteractswithLRDD. TISSUESPECIFICITY:Expressedinlargeramountsintheembryoniclung,liverandkidneythanintheheartandbrain.Intheadultshigherlevelexpressionisseenintheplacenta,lung,kidney,pancreasthanintheheart,brain,liverandskeletalmuscle. PTM:Thematureproteasecanprocessitsownpropeptide,butnotthatofothercaspases. SIMILARITY:SwissProt:P42575##BelongstothepeptidaseC14family.&Contains1CARDdomain. |