| Immunogen | KLH-conjugatedsyntheticpeptidecomposedofresiduesattheN-terminusofhumanCaspase-9. |
| Host | Rabbit |
| Specificity | RecognizesaregioncomposedofresiduesattheN-terminusofhumanPro-Caspase-9.Thisantibodyonlybindstothepro-formofCaspase-9. |
| Isotype | IgG |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.ThisproteinisprocessedbycaspaseAPAF1;thisstepisthoughttobeoneoftheearliestinthecaspaseactivationcascade.Alternativesplicingresultsintwotranscriptvariantswhichencodedifferentisoforms. |
| GeneSymbol | - CASP9
- CASP-9
- ICE-LAP6
- MCH6
- APAF3
- CASPASE-9c
- OTTHUMP00000044594
- APAF-3
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55211#Isoform2lacksactivityisandominant-negativeinhibitorofcaspase-9. SIZE:416aminoacids;46281Da SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya35kDa(p35)anda10kDa(p10)subunit.Caspase-9andAPAF1bindtoeachotherviatheirrespectiveNH2-terminalCED-3homologousdomainsinthepresenceofcytochromeCandATP.InteractswiththeinhibitorsBIRC2,BIRC4,BIRC5andBIRC7. TISSUESPECIFICITY:Ubiquitous,withhighestexpressionintheheart,moderateexpressioninliver,skeletalmuscle,andpancreas.Lowlevelsinallothertissues. PTM:CleavagesatAsp-315bygranzymeBandatAsp-330bycaspase-3generatethetwoactivesubunits.Caspase-8and-10canalsobeinvolvedintheseprocessingevents. SIMILARITY:SwissProt:P55211##BelongstothepeptidaseC14family.&Contains1CARDdomain. |
| MolecularWeight | 46kDa |