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    當前位置 ： Millipore >>> Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL
    Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL
    • Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL

    Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL

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    貨號: 04-1103
    品牌: Millipore
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      • Description
        CatalogueNumber04-1103
        DescriptionAnti-E-cadherinAntibody,cloneEP700Y,rabbitmonoclonal
        AlternateNames
        • CAM120/80
        • CD324antigen
        • cadherin1
        • E-cadherin(epithelial)
        • cadherin1,type1
        BackgroundInformationCadherinsareafamilyoftransmembraneglycoproteinsinvolvedinCa2+-dependentcelltocellinteractions.Themembersofthefamilyaredifferentiallyexpressedinvarioustissuesandfunctioninthemaintenanceoftissueintegrity,morphogenesis,andmigration.CadherinsaredividedintotypeIandtypeIIsubgroups.TypeIcadherinsincludeepithelialcadherin(E-cadherin),neuralcadherin(N-cadherin),placentalcadherin(P-cadherin)andretinalcadherin(R-cadherin).TypeIIincludekidneycadherin(K-cadherin)andosteoblastcadherin(OB-cadherin).OneofthebestcharacterizedcadherinsisE-cadherin(epithelialcadherinorcadherin-1).ItconsistsofcalciumbindingextracellulardomainsresponsIBLeforinteractionswithotherE-cadherinmoleculesonneighboringcellsandinteractionwithintegrinalphaEbeta7.ThecytoplasmicdomainofE-cadherinislinkedtotheactinCytoskeletonthroughcytoplasmiccateninproteins,thusestablishingacomplexlocalizedtoadherensjunctions.IncarcinomasE-cadherinisfrequentlydownregulated,whichisconsistentwithitsfunctionofaninvasionsuppressorinnormalepithelia.
        ProductInformation
        FormatUnpurified
        Control
        • MCF-7celllysates.
        PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectE-cadherinusingthisAnti-E-cadherinAntibody,cloneEP700Y,RabbitvalidatedforuseinIH(P),WB,IC&IP.
        KeyApplications
        • Immunohistochemistry(Paraffin)
        • WesternBlotting
        • Immunocytochemistry
        • Immunoprecipitation
        ApplicationNotesImmunohistochemistryAnalysis:1:500dilutionfromapreviouslotdetectedE-cadherininhumanbreastcarcinomaandhepatocellularcarcinomatissue.
        Immunocytochemistry:1:500dilutionfromapreviouslotwasusedonIC.
        Immunoprecipitation:1:50dilutionfromapreviouslotwasusedonIP.
        BIOLOGicalInformation
        ImmunogenSyntheticpeptidecorrespondingtoresiduesinthe5thcadherindomainofhumanE-cadherin.
        CloneEP700Y
        HostRabbit
        SpecificityThisantibodyrecognizesE-cadherin.
        IsotypeIgG
        SpeciesReactivity
        • Human
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        GeneSymbol
        • Arc-1
        • CD324
        • CDHE
        • Cadherin-1
        • E-cadherin
        • ECAD
        • LCAM
        • UVO
        • Uvomorulin
        • uvomorulin
        PurificationMethodUnpurified
        UniProtNumber
        UniProtSummaryFUNCTION:Cadherinsarecalcium-dependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.CDH1isinvolvedinmechanismsregulatingcell-celladhesions,mobilityandproliferationofepithelialcells.Hasapotentinvasivesuppressorrole.Itisaligandforintegrinalpha-E/beta-7.
        E-Cad/CTF2promotesnon-amyloidogenicdegradationofAbetaprecursors.HasastronginhibitoryeffectonAPPC99andC83production.
        SUBUNITSTRUCTURE:Homodimer;disulfide-linked.Interactsdirectly,viathecytoplasmicdomain,withCTNNB1orJUPtoformthePSEN1/cadherin/cateninadhesioncomplexwhichconnectstotheactinskeletonthroughtheactinbindingofalpha-catenin.InteractionwithPSEN1,cleavesCDH1resultinginthedisassociationofcadherin-basedadherensjunctions(CAJs).InteractswithAJAP1,CTNND1andDLGAP5.
        SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:ColocalizeswithDLGAP5atsitesofcell-cellcontactinintestinalepithelialcells.AnchoredtoactinMICROFILamentsthroughassociationwithalpha-,beta-andgamma-catenin.Sequentialproteolysisinducedbyapoptosisorcalciuminflux,resultsintranslocationfromsitesofcell-cellcontacttothecytoplasm.
        TISSUESPECIFICTIY:Non-neuralepithelialtissues.
        PTM:Duringapoptosisorwithcalciuminflux,cleavedbyamembrane-boundmetalloproteinase(ADAM10),PS1/gamma-secretaseandcaspase-3toproducefragmentsofabout38kDa(E-CAD/CTF1),33kDa(E-CAD/CTF2)and29kDa(E-CAD/CTF3),respectively.Processingbythemetalloproteinase,inducedbycalciuminflux,causesdisruptionofcell-celladhesionandthesubsequentreleaseofbeta-cateninintothecytoplasm.Theresidualmembrane-tetheredcleavageproductisrapidlydegradedviaanintracellularproteolyticpathway.Cleavagebycaspase-3releasesthecytoplasmictailresultingindisintegrationoftheactinmicrofilamentsystem.Thegamma-secretase-mediatedcleavagepromotesdisaaaemblyofadherensjunctions.
        INVOLVEMENTINDISEASE:DefectsinCDH1areinvolvedindysfunctionofthecell-celladhesionsystem,triggeringcancerinvasion(gastric,breast,ovary,endometriumandthyroid)andmetastasis.
        DefectsinCDH1areacauseofgastriccancer[MIM:137215];alsoknownashereditaryfamilialdiffusegastriccancer(HDGC).
        DefectsinCDH1areacauseofsusceptibilitytoendometrialcancer[MIM:608089].
        DefectsinCDH1areassociatedwithovariancancer[MIM:167000].OvariancanceristheleADIngcauseofdeathfromgynecologicmalignancy.Itischaracterizedbyadvancedpresentationwithloco-regionaldisseminationintheperitonealcavityandtherareincidenceofvisceralmetastases.Thesetypicalfeaturesrelatetothebiologyofthedisease,whichisaprincipaldeterminantofoutcome.
        SEQUENCESIMILARITIES:Contains5cadherindomains.
        SEQUENCECAUTION:ThesequenceAAA61259.1differsfromthatshown.Reason:Frameshiftatpositions16,22,25,28,31,34,52,67,73,76,94,102,633and636.
        MolecularWeight~135/80kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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