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    當前位置 ： Millipore >>> Millipore/04-1070 | Anti-phospho-β-Catenin(Ser33/Ser37) Antibody, clone EP742(2)Y, rabbit monoclonal/04-1070/100 µ
    Millipore/04-1070 | Anti-phospho-β-Catenin(Ser33/Ser37) Antibody, clone EP742(2)Y, rabbit monoclonal/04-1070/100 µ
    • Millipore/04-1070 | Anti-phospho-β-Catenin(Ser33/Ser37) Antibody, clone EP742(2)Y, rabbit monoclonal/04-1070/100 µ

    Millipore/04-1070 | Anti-phospho-β-Catenin(Ser33/Ser37) Antibody, clone EP742(2)Y, rabbit monoclonal/04-1070/100 µ

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    貨號: 04-1070
    品牌: Millipore
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      • Description
        CatalogueNumber04-1070
        DescriptionAnti-phospho-β-Catenin(Ser33/Ser37)Antibody,cloneEP742(2)Y,rabbitmonoclonal
        AlternateNames
        • catenin(cadherin-associatedprotein),beta1(88kD)
        • catenin(cadherin-associatedprotein),beta1,88kDa
        • cateninbeta-1
        BackgroundInformationβ-CateninlinksCadherincelladhesionproteinstotheCytoskeletonandhasrecentlybeenimplicatedintheWnt/Winglesssignalingpathwayandintheprogressionofneoplasia.β-CateninassociateswiththetumorsuppressorAdenomatousPolypopsisColi(APC)andfunctionsasaco-activatoroftheTCFtranscriptionfactorfamily.ItisregulatedbyGlycogenSynthaseKinase(GSK)3b,whichphosphorylatesandtargetsβ-Cateninforubiquitin-mediatedproteolysis.StABIlizationofβ-Catenin,eitherbyWnt-mediatedinhibitionofGSK3borbymutation(asfoundinnumerouscolorectaltumorsandmelanomacelllines),resultsinactivationofTCFresponsivegeneswhicharethoughttoplaykeyrolesindevelopmentandcancerprogression.δ-Catenin(NPRAP/Neurojungin),amemberofthep120Cateninsubfamily,isastructuralproteininvolvedinneuronaldevelopment.ItinteractswithActin,CortactinandSrcKinasestopromoteneuriteelongationorbranching,dependinguponitsphosphorylationstate.
        ProductInformation
        FormatUnpurified
        Control
        • 293Tcelllysates
        PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Detectphospho-β-Catenin(Ser33/Ser37)usingthisAnti-phospho-β-Catenin(Ser33/Ser37)Antibody,cloneEP742(2)Y,RabbitvalidatedforuseinWB.
        KeyApplications
        • WesternBlotting
        BIOLOGicalInformation
        ImmunogenPhospho-specificpeptidecorrespondingtoresiduessurroundingSerine33andSerine37ofhumanβ-catenin.
        Epitopephospho-Ser33/Ser37
        CloneEP742(2)Y
        HostRabbit
        SpecificityThisantibodydetectsβ-cateninphosphorylatedonSerine33and/orSerine37neartheN-terminus.
        IsotypeIgG
        SpeciesReactivity
        • Human
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryBeta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactincytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM].

        GeneSymbol
        • Beta-catenin
        • CTNNB
        • DKFZp686D02253
        • FLJ25606
        • FLJ37923
        • OTTHUMP00000165222
        • OTTHUMP00000165223
        Modifications
        • Phosphorylation
        PurificationMethodUnpurified
        UniProtNumber
        UniProtSummaryFUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.
        SUBUNITSTRUCTURE:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.Thestabilizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andCHD8.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1bindingBysimilarity.InteractswithTAX1BP3(viathePDZdomain);thisinteractioninhibitsthetranscriptionalactivityofCTNNB1Bysimilarity.InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2andMUC1.InteractswithSLC30A9.InteractswithXIRP1Bysimilarity.InteractswithPTPRU(viathecytoplasmicjuxtamembranedomain).
        SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cytoplasm?cytoskeleton.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2andMUC1promotesnucleartranslocation.
        TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.
        PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33.
        EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding.
        UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1XProbable.Itsubiquitinationleadstoitssubsequentproteasomaldegradation.
        DISEASE:ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife.
        DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor.
        DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren.
        AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1.
        SIMILARITY:Belongstothebeta-cateninfamily.
        Contains12ARMrepeats.
        MolecularWeight~92kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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