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    當前位置 ： Millipore >>> Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL
    Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL
    • Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL

    Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL

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    貨號: 04-1046
    品牌: Millipore
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      • Description
        CatalogueNumber04-1046
        DescriptionAnti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,Rabbit|04-1046
        AlternateNames
        • Translocation-associatednotchproteinTAN-1
        • neurogeniclocusnotchhomologprotein1
        BackgroundInformationNotchisthereceptorforDeltaandJaggedligands,whichcauseproteolysisofnotchtoliberatetheintracellulardomain.ThatdomaintranslocatestothenucleusandinitiatestranscriptioneventsbybindingtheDNAbindingproteinCSL.Thenotchfamilymembersareinvolvedinnumerousdifferentiationandcelllineagedeterminationsteps.
        ProductInformation
        FormatPurified
        Control
        • Hek293celllysates
        PresentationRabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.18MNaClcontaining40%Glycerol,0.25%sodiumazide,0.25mMEDTA,25mMCitricAcid,and0.5%BSA.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Anti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,RabbitdetectslevelofNotch1(Cytoplasmic)&hasbeenpublished&validatedforuseinWB,IC,IH.
        KeyApplications
        • WesternBlotting
        • Immunocytochemistry
        • Immunohistochemistry
        ApplicationNotesImmunohistochemistryAnalysis:1:50-100dilutionfromapreviouslotdetectedNotch1inHumanfetallungtissue.
        BIOLOGicalInformation
        ImmunogenSyntheticpeptidecorrespondingtothecytoplasmicdomainofhumanNotch1
        EpitopeCytoplasmicDomain
        CloneEP1238Y
        HostRabbit
        SpecificityThisantibodyrecognizesthecytoplasmicdomainofNotch1
        IsotypeIgG
        SpeciesReactivity
        • Human
        • Mouse
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.[providedbyRefSeq]
        GeneSymbol
        • TAN1
        • hN1
        • notch1
        UniProtNumber
        UniProtSummaryFUNCTION:Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmanngliaBysimilarity.
        SUBUNITSTRUCTURE:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.Ref.6Ref.7Ref.8
        SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneproteinBysimilarity.
        Notch1intracellulardomain:NucleusBysimilarity.Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleusBysimilarity.
        TISSUESPECIFICTY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.
        PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembraneBysimilarity.
        PhosphorylatedBysimilarity.
        INVOLVEMENTINDISEASE:NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.Ref.13
        DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.
        SEQUENCESIMILARITIES:BelongstotheNOTCHfamily.
        Contains5ANKrepeats.
        Contains36EGF-likedomains.
        Contains3LNR(Lin/Notch)repeats.
        MolecularWeight~125kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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