| Immunogen | SyntheticpeptidecorrespondingtoresiduesinthetaildomainofhumanNeurofilament-66. |
| Epitope | TailDomain |
| Clone | EP676Y |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesNeurofilament-66atandaroundthetaildomain. |
| Isotype | IgG |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | NeurofilamentsaretypeIVintermediatefilamentheteropolymerscomposedoflight,medium,andheavychains.Neurofilamentscomprisetheaxoskeletonandtheyfunctionallymaintaintheneuronalcaliber.Theymayalsoplayaroleinintracellulartransporttoaxonsanddendrites.Thisgeneisamemberoftheintermediatefilamentfamilyandisinvolvedinthemorphogenesisofneurons. |
| GeneSymbol | - Alpha-Inx
- FLJ18662
- FLJ57501
- MGC12702
- NEF5
- NF-66
- Neurofilament-66
- OTTHUMP00000020403
- TXBP-1
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges. TISSUESPECIFICITY:FoundpredominantlyinadultCNS. DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation. PTM:O-glycosylatedBysimilarity. PhosphorylateduponDNAdamage,probablybyATMorATR. SEQUENCESIMILARITIES:Belongstotheintermediatefilamentfamily. |
| MolecularWeight | ~66kDa |