• <menu id="uuusw"></menu>
    •
  • <table id="uuusw"></table>
    當前位置 ： Millipore >>> Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL
    Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL
    • Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL

    Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL

    價格: 試用 市場價: 0.00
    打印產品信息
    貨號: MABE16
    品牌: Millipore
    規格
    數量
    庫存(0)
    特別 提示
    代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
    下單后請及時聯系客服核對商品價格，訂單生效后再付款。
    立即申請

    收藏商品
    資深產品顧問
    咨詢顧問

    全國免費服務熱線

    4000-520-616

    • 自營商城 一站式服務
    • 廠家直采 剔除溢價
    • 品質甄選 正品保證
    • 嚴控流程 只做188精品
    • 極速物流 如約送貨
    • 詳情
    • 使用說明
    • 常見問題
      • Description
        CatalogueNumberMABE16
        DescriptionAnti-phosphoSir2/SIRT1(Ser47)Antibody,cloneEPR2849Y,rabbitmonoclonal
        AlternateNames
        • SIR2-likeprotein1
        • sirtuin(silentmatingtypeinformationregulation2homolog)1(S.cerevisiae)
        • sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)1
        BackgroundInformationTheS.cerevisiaesilentinformationregulator2(Sir2)proteinisanNAD+-dependenthistonedeacetylase(HDACs)thatplaysacriticalroleintranscriptionalsilencing,genomestABIlity,andlongevity(1-2).PartoftheSirtuinfamily(Sir2,Sir3,Sir3),yeastSir2isthefoundingmemberofClassIIIHDACs.AhumanhomologueofSir2,SIRT1,regulatestheactivityofthep53tumorsuppressorandinhibitsapoptosis(3-4).
        ProductInformation
        FormatUnpurified
        Control
        • LamBDaphosphatase(LP)-treatedanduntreated293celllysates.
        PresentationRabbitmonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
        HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
        Applications
        ApplicationUseAnti-phosphoSir2/SIRT1(Ser47)Antibody,cloneEPR2849Y(RabbitMonoclonalAntibody)validatedinWB,IHC,ICCtodetectphosphoSir2/SIRT1(Ser47)alsoknownasSIR2-likeprotein1orsirtuin1.
        KeyApplications
        • WesternBlotting
        • Immunohistochemistry
        • Immunocytochemistry
        ApplicationNotesImmunohistochemistryAnalysis:A1:250–1:500dilutionfromapreviouslotdetectedSir2/SIRT1inIH.
        ImmunocytochemistryAnalysis:A1:100–1:250dilutionfromapreviouslotdetectedSir2/SIRT1inIC.
        BIOLOGicalInformation
        ImmunogenPhospho-specificpeptidecorrespondingtohumanSir2/SIRT1atSer47.
        EpitopeSer47
        CloneEPR2849Y
        HostRabbit
        SpecificityThisantibodydetectsSir2/SIRT1phosphorylatedonSer47.
        IsotypeIgG
        SpeciesReactivity
        • Human
        SpeciesReactivityNoteProventoreactwithhuman.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        GeneSymbol
        • sirtuin1
        • SIR2L1
        • hSIR2
        • hSIRT1
        Modifications
        • Phosphorylation
        PurificationMethodUnpurified
        UniProtNumber
        UniProtSummaryFUNCTION:NAD-dependentproteindeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsabilitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD+/NADH,whichisessentialinskeletalmusclecelldifferentiation.Deacetylates"Lys-16"ofhistoneH4(invitro).ComponentoftheeNoSC(energy-dependentnucleolarsilencing)complex,acomplexthatmediatessilencingofrDNAinresponsetointracellularenergystatusandactsbyrecruitinghistone-modifyingenzymes.TheeNoSCcomplexisabletosensetheenergystatusofcell:uponglucosestarvation,elevationofNAD+/NADP+ratioactivatesSIRT1,leADIngtohistoneH3deacetylationfollowedbydimethylationofH3at"Lys-9"(H3K9me2)bySUV39H1andtheformationofsilentchromatinintherDNAlocus.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein.
        CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.
        COFACTOR:Binds1zincionpersubunitBysimilarity.
        ENZYMEREGULATION:Inhibitedbynicotinamide.Activatedbyresveratrol(3,5,4"-trihydroxy-trans-stilbene),butein(3,4,2",4"-tetrahydroxychalcone),piceatannol(3,5,3",4"-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2",4"-trihydroxychalcone),fisetin(3,7,3",4"-tetrahydroxyflavone)andquercetin(3,5,7,3",4"-pentahydroxyflavone).RPS19BP1/AROSactsasapositiveregulatorofdeacetylationactivity.NegativelyregulatedbyKIAA1967/DBC1.
        SUBUNITSTRUCTURE:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1Bysimilarity.ComponentoftheeNoSCcomplex,composedofSIRT1,SUV39H1andRRP8.InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML.InteractswithRPS19BP1/AROS.InteractswithKIAA1967/DBC1(viaN-terminus).
        SUBCELLULARLOCATION:Nucleus?PMLbody.Note:RecruitedtothenuclearbodiesviaitsinteractionwithPML.
        TISSUESPECIFICITY:Widelyexpressed.
        MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedLifespanasithasbeenobservedinyeast.
        SEQUENCESIMILARITIES:Belongstothesirtuinfamily.
        Contains1deacetylasesirtuin-typedomain.
        SEQUENCECAUTIONS:ThesequenceAAH12499.1differsfromthatshown.Reason:Erroneousinitiation.
        MolecularWeight~110kDaobserved
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
      售后保障
      螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。
    • Q：生物188產品正品保障嗎？
      A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購， 自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

      Q：下單后可以修改訂單嗎？
      A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

      Q：可以開發票嗎？
      A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

      Q：商品幾天可以發貨？
      A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

      Q：如何聯系商家？
      A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

      Q：收到的商品少了/發錯了怎么辦？
      A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是 部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

      Q：退換貨/維修需要多長時間？
      A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、 數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

    客戶服務

    在線客服
    用戶反饋

    何為188

    極簡而嚴謹，我們僅銷售188款生物醫學科研用品，款款都是爆款；因為少所以聚焦，聚焦甄選每一款產品，聚焦服務每一位客戶!

    關注我們 :

    點擊QQ聯系我們
    生物188微信

    關注188微信公眾號

    獲取最新優惠活動通知

    • 品質甄選，正品保證

    • 自營電商，廠家直采

    • 極簡主義，188精品

    常見問題 | 購買相關 | 配送與驗收 | 支付問題 | 售后與服務 | 服務協議 | 隱私政策 | 何為188 | 中國智造 | 聯系我們
    友情鏈接： Immuno Star中國 | Paragon Genomics價格 | edmondcarine華東代理 | Macrocyclics廠家 | expressionsystems代理 | 螞蟻淘 | 粗纖維測定儀

    公司版權所有 ? 2005-2021 蘇州螞蟻淘生物科技有限公司 蘇ICP備17049038號-10

  • <menu id="uuusw"></menu>
    •
  • <table id="uuusw"></table>
    上床视频