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    當前位置 ： Millipore >>> Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL
    Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL
    • Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL

    Millipore/MAB382 | Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1/MAB382/2 mL

    價格: ￥5424.00 市場價: 9040.00
    打印產品信息
    貨號: MAB382
    品牌: Millipore
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      • Description
        CatalogueNumberMAB382
        BrandFamilyChemicon®
        TradeName
        • Chemicon
        DescriptionAnti-MyelinBasicProteinAntibody,a.a.129-138,clone1
        AlternateNames
        • MyelinA1protein
        • Myelinmembraneencephalitogenicprotein
        • myelinbasicprotein
        BackgroundInformationTheclassicgroupofMBPisoforms(isoforms4-14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.TheyhavearoleinbothitsformationandstABIlization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoforms1-3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalposttranslationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.

        MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.

        Isoform1Golli-MBP1,HOG7,33kDa

        Isoform2Golli-MBP2,HOG5,21.5kDa

        Isoform3MBP1,21.5kDa

        Isoform4MBP2,20.2kDa

        Isoform5MBP3,18.5kDa

        Isoform6MBP4,17.2kDa

        (SP_P02686)
        ProductInformation
        FormatCultureSupernatant
        Control
        • Braintissue
        PresentationCulturesupernatantcontaining0.2MTris/HCl,pH7.4with5-10%fetalcalfserumand0.1%sodiumazide
        StorageandShippingInformation
        StorageConditionsStablefor1yearat-20oCinundilutedaliquotsfromdateofreceipt.
        HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
        Applications
        ApplicationThisAnti-MyelinBasicProteinAntibody,a.a.129-138,clone1isvalidatedforuseinELISA,IH,IH(P),RIA,WBforthedetectionofMyelinBasicProtein.
        KeyApplications
        • ELISA
        • Immunohistochemistry
        • Immunohistochemistry(Paraffin)
        • RADIoimmunoassay
        • WesternBlotting
        ApplicationNotesImmunohistochemistry(paraffin)Analysis:
        OptimalStainingWithCitrateBuffer,pH6.0,EpitopeRetrieval:RatCerebellum
        Immunohistologyonfrozensectionsat1:10

        WesternBlotAnalysis:
        ApreviouslotofthisantibodywasusedinWesternBlot.

        ELISA:
        A1:200-1:1,000dilutionofapreviouslotwasusedinELISA.

        RIA:
        ApreviouslotofthisantibodywasusedinRadioimmunoassay.

        Optimalworkingdilutionsmustbedeterminedbyenduser.
        BIOLOGicalInformation
        ImmunogenBovinemyelinbasicprotein
        Epitopea.a.129-138
        Clone1
        ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
        HostMouse
        SpecificityReactswithMBPfromhuman,bovineandrat,epitope129-138
        IsotypeIgG2a
        SpeciesReactivity
        • Bovine
        • Human
        • Rat
        SpeciesReactivityNoteReactsweaklywithrabbit.Doesnotreactwithguineapig.
        AntibodyTypeMonoclonalAntibody
        EntrezGeneNumber
        EntrezGeneSummaryTheproteinencodedbytheclassicMBPgeneisamajorconstituentofthemyelinsheathofoligodendrocytesandSchwanncellsinthenervoussystem.However,MBP-relatedtranscriptsarealsopresentinthebonemarrowandtheimmunesystem.ThesemRNAsarisefromthelongMBPgene(otherwisecalled"Golli-MBP")thatcontains3additionalexonslocatedupstreamoftheclassicMBPexons.AlternativesplicingfromtheGolliandtheMBPtranscriptionstartsitesgivesriseto2setsofMBP-relatedtranscriptsandgeneproducts.TheGollimRNAscontain3exonsuniquetoGolli-MBP,splicedin-frameto1ormoreMBPexons.TheyencodehybridproteinsthathaveN-terminalGolliaasequencelinkedtoMBPaasequence.ThesecondfamilyoftranscriptscontainonlyMBPexonsandproducethewellcharacterizedmyelinbasicproteins.ThiscomplexgenestructureisconservedamongspeciessuggestingthattheMBPtranscriptionunitisanintegralpartoftheGollitranscriptionunitandthatthisarrangementisimportantforthefunctionand/orregulationofthesegenes.
        GeneSymbol
        • MBP
        • MGC99675
        • Golli-mbp
        PurificationMethodUnpurified
        UniProtNumber
        UniProtSummaryFUNCTION:SwissProt:P02686#TheclassicgroupofMBPisoforms(isoform4-isoform14)arewithPLPthemostabundantproteincomponentsofthemyelinmembraneintheCNS.Theyhavearoleinbothitsformationandstabilization.Thesmallerisoformsmighthaveanimportantroleinremyelinationofdenudedaxonsinmultiplesclerosis.Thenon-classicgroupofMBPisoforms(isoform1-isoform3/Golli-MBPs)maypreferentiallyhavearoleintheearlydevelopingbrainlongbeforemyelination,maybeascomponentsoftranscriptionalcomplexes,andmayalsobeinvolvedinsignalingpathwaysinT-cellsandneuralcells.Differentialsplicingeventscombinedtooptionalpost-translationalmodificationsgiveawidespectrumofisomers,eachofthemhavingmaybeaspecializedfunction.InducesT-cellproliferation.
        SIZE:304aminoacids;33117Da
        SUBUNIT:Homodimer;isoform3existsasahomodimer.
        SUBCELLULARLOCATION:Myelinmembrane;Peripheralmembraneprotein;Cytoplasmicside.Note=Cytoplasmicsideofmyelin.
        TISSUESPECIFICITY:MBPisoformsarefoundinboththecentralandtheperipheralnervoussystem,whereasGolli-MBPisoformsareexpressedinfetalthymus,spleenandspinalcord,aswellasincelllinesderivedfromtheimmunesystem.DEVELOPMENTALSTAGE:Expressionturnsonabruptlyinfetusof14to16weeks.Evensmallerisoformsseemtobeproducedduringembryogenesis,someofthesepersistingintheadult.ExpressionofisoformMBP2ismoreevidentat16weeksanditsrelativeproportiondeclinedthereafter.
        PTM:SeveralchargeisomersofMBP;C1(themostcationic,leastmodified,andmostabundantform),C2,C3,C4,C5,C6,C7,C8-AandC8-B(theleastcationicform);areproducedasaresultofoptionalPTM,suchasphosphorylation,deamidationofglutamineorasparagine,argininecitrullinationandmethylation.C8-AandC8-BcontaineachtwomassisoformstermedC8-A(H),C8-A(L),C8-B(H)andC8-B(L),(H)standingforhigherand(L)forlowermolecularweight.C3,C4andC5arephosphorylated.Theratioofmethylatedarginineresiduesdecreasesinaging,makingtheproteinmorecationic.&TheN-terminalalanineisacetylated(isoform3,isoform4,isoform5andisoform6).&Arg-241wasfoundtobe6%monomethylatedand60%symmetricallydimethylated.
        DISEASE:SwissProt:P02686#Thereductioninthesurfacechargeofcitrullinatedand/ormethylatedMBPcouldresultinaweakenedattachmenttothemyelinmembrane.Thismechanismcouldbeoperativeindemyelinatingdiseasessuchaschronicalmultiplesclerosis(MS),andfulminatingMS(Marburgdisease).
        SIMILARITY:SwissProt:P02686##Belongstothemyelinbasicproteinfamily.
        MolecularWeight19kDa
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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