| Immunogen | TyrosineHydroxylasepurifiedfromPC12cells |
| Clone | LNC1 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | RecognizesanepitopeontheoutsideoftheregulatoryN-terminus.Recognizesaproteinofapproximately59-61kDabyWesternblot.DoesnotreactwiththefollowingonWesternBlots:dopamine-beta-hydroxylase,phenylalaninehydroxylase,trytophanhydroxylase,dehydropteridinereductase,sepiapterinreductaseorphenethanolamine-N-methyltransferase(PNMT). |
| Isotype | IgG1κ |
| SpeciesReactivity | - Chicken
- Frog
- Human
- Mouse
- Monkey
- Rat
- Lizard
- Vole
- Zebrafish
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
| GeneSymbol | |
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
| MolecularWeight | 59-63kDa |