| Immunogen | AffinitypurifiedextracellulardomainofhumanK-cadherin |
| Epitope | extracellulardomain |
| Clone | 2B6 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | ReactswiththeextracellulardomainofK-cadherin. |
| Isotype | IgG1 |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesatypeIIclassicalcadherinfromthecadherinsuperfamily.Theencodedmembraneproteinisacalciumdependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.Cadherinsmediatecell-cellbindinginahomophilicmanner,contributingtothesortingofheterogeneouscelltypesandthemaintenanceoforderlystructuressuchasepithelium.Strongtranscriptionalexpressionofthisgenehasbeenobservedinhepatocellularandrenalcarcinomacelllines,suggestingapossibleroleinmetastasisandinvasion. |
| GeneSymbol | |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55285#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes. SIZE:790aminoacids;88309Da SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Highlyexpressedinbrain,cerebellum,andkidney.Lung,pancreas,andgastricmucosashowaweakexpression.Alsoexpressedincertainliverandkidneycarcinomas. SIMILARITY:SwissProt:P55285##Contains5cadherindomains. |