| Immunogen | GSTfusionproteinwithresidues249-323ofratAquaporin4(SwissProtaccessionnumberP47863).Itisexpectedthattheantibodymayalsoreactwithmouse(73/75),bovine(71/75),human(69/75)andrabbit(64/75)duetosequencehomology. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | Recognizesaquaporin4.Onwesternblotsofratbrainmembranes,theantibodydetectsabandmigratingatapproximately38kDacorrespondingtoaquaporin4. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberoftheaquaporinfamilyofintrinsicmembraneproteinsthatfunctionaswater-selectivechannelsintheplasmamembranesofmanycells.Theencodedproteinisthepredominantaquaporinfoundinbrain.Twoalternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene. |
| GeneSymbol | - AQP4
- MIWC
- WCH4
- AQP-4
- aquaporin-4
- HMIWC2
- Aquaporin-4
- MGC22454
|
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P55087#Formsawater-specificchannel.Osmoreceptorwhichregulatesbodywaterbalanceandmediateswaterflowwithinthecentralnervoussystem. SIZE:323aminoacids;34830Da SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Brain-muscle>heart,kidney,lung,andtrachea. DOMAIN:SwissProt:P55087Aquaporinscontaintwotandemrepeatseachcontainingthreemembrane-spanningdomainsandapore-formingloopwiththesignaturemotifAsn-Pro-Ala(NPA). SIMILARITY:BelongstotheMIP/aquaporin(TC1.A.8)family. |
| MolecularWeight | 38kDa |