The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier"s disease and familial high-density lipoprotein deficiency.
Product NameABCA1 Polyclonal AntibodyABCA1 Rabbit pAbABCA1; ABC-1; ABC1; CERP;HDLDT1; TGD
Host Species Rabbit
Purification Method Affinity purification
IsotypeIgG
Storage/HandlingStore at -20℃.Avoid freeze / thaw cycles.
Storage BufferPBS with 0.02% sodium azide, 50%glycerol, pH7.3.
Immunogen Information
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1870-2120 of human ABCA1 (NP_005493.2).
Sequence IQYRFFIRPR PVNAKLSPLN DEDEDVRRER QRILDGGGQN DILEIKELTK IYRRKRKPAV DRICVGIPPG ECFGLLGVNG AGKSSTFKML TGDTTVTRGD AFLNKNSILS NIHEVHQNMG YCPQFDAITE LLTGREHVEF FALLRGVPEK EVGKVGEWAI RKLGLVKYGE KYAGNYSGGN KRKLSTAMAL IGGPPVVFLD EPTTGMDPKA RRFLWNCALS VVKEGRSVVL TSHSMEECEA LCTRMAIMVN G
Gene ID: 19Swiss Protein: O95477
Calculated MW: 254 kDa
Observed MW: 254 kDa
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4000-520-616
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