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    當前位置 ： Millipore >>> Millipore/09-203 | Anti-phospho-JAK2 (Tyr868) Antibody/09-203/100 µL
    Millipore/09-203 | Anti-phospho-JAK2 (Tyr868) Antibody/09-203/100 µL
    • Millipore/09-203 | Anti-phospho-JAK2 (Tyr868) Antibody/09-203/100 µL

    Millipore/09-203 | Anti-phospho-JAK2 (Tyr868) Antibody/09-203/100 µL

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    貨號: 09-203
    品牌: Millipore
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      • Description
        CatalogueNumber09-203
        DescriptionAnti-phospho-JAK2(Tyr868)Antibody
        BackgroundInformationJAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerize,translocatetothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.WithintheJAK2kinasedomain,thereisaregionthathasconsiderablesequencehomologytotheregulatoryregionoftheinsulinreceptor.
        ProductInformation
        FormatAffinityPurified
        PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.
        StorageandShippingInformation
        StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
        Applications
        ApplicationAnti-phospho-JAK2(Tyr868)Antibodydetectslevelofphospho-JAK2(Tyr868)&hasbeenpublished&validatedforusein0.
        KeyApplications
        • WesternBlotting
        ApplicationNotesWesternBlot(SNAPID)Analysis:1:50dilutionfromapreviouslotdetectedphospho-JAK2on10μgofcelllysatesofHEK293TstimulatedwithSH2b1beta.
        BIOLOGicalInformation
        ImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheproteinkinase2domainofhumanphospho-JAK2.
        EpitopeProteinkinase2domain
        HostRabbit
        SpecificityThisantibodyrecognizestheproteinkinase2domainofJAK2.
        SpeciesReactivity
        • Human
        • Mouse
        SpeciesReactivityNoteDemonstratedtoreactwithhumanandmouse.Predictedtoreactwithrat,equine,opossum,bovine,chimpanzee,porcine,ape,andplatypusbasedon100%sequencehomology.
        AntibodyTypePolyclonalAntibody
        UniProtNumber
        UniProtSummaryFUNCTION:PlaysaroleinleptinsignalingandcontrolofbodyweightBysimilarity.Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction.

        CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.

        SUBUNITSTRUCTURE:InteractswithSIRPAandSH2B1Bysimilarity.InteractswithIL23R,SKB1andSTAM2.

        SUBCELLULARLOCATION:Endomembranesystem;PeripheralmembraneproteinBysimilarity.Note:Whollyintracellular,possIBLymembraneassociatedBysimilarity.

        TISSUESPECIFICITY:Expressedinblood,bonemarrowandlymphnode.

        DOMAIN:Possessestwophosphotransferasedomains.ThesecondoneprobablycontainsthecatalyticdomainBysimilarity,whilethepresenceofslightdifferencessuggestadifferentrolefordomain1.

        PTM:Leptinpromotesphosphorylationontyrosineresidues,includingphosphorylationonTyr-813Bysimilarity.

        INVOLVEMENTINDISEASE:ChromosomalaberrationsinvolvingJAK2arefoundinbothchronicandacuteformsofeosinophilic,lymphoblasticandmyeloidleukemia.Translocationt(8;9)(p22;p24)withPCM1linkstheproteinkinasedomainofJAK2tothemajorportionofPCM1.Translocationt(9;12)(p24;p13)withETV6.DefectsinJAK2areacauseofsusceptibilitytoBudd-Chiarisyndrome[MIM:600880].Budd-Chiarisyndromeisaspectrumofdiseasestates,includinganatomicabnormalitiesandhypercoagulabledisorders,resultinginhepaticvenousoutflowocclusion.Clinicalmanifestationsobservedinthemajorityofpatientsincludehepatomegaly,rightupperquadrantpain,andaBDominalascites.

        DefectsinJAK2areassociatedwithpolycythemiavera(PV)[MIM:263300].PV,themostcommonformofprimarypolycythemia,iscausedbysomaticmutationinasinglehematopoieticstemcellleADIngtoclonalhematopoiesis.PVisamyeloproliferativedisordercharacterizedpredominantlybyerythroidhyperplasia,butalsobymyeloidleukocytosis,thrombocytosis,andsplenomegaly.FamilialcasesofPVareveryrareandusuallymanifestinelderlypatients.

        DefectsinJAK2genemaybeacauseofessentialthrombocythemia(ET)[MIM:187950].ETischaracterizedbyelevatedplateletlevelsduetosustainedproliferationofmegakaryocytes,andfrequentlyleadtothromboticandhaemorrhagiccomplications.

        DefectsinJAK2areassociatedwithfamilialmyelofibrosis[MIM:254450].Myelofibrosiswithmyeloidmetaplasiaisamyeloproliferativediseasewithannualincidenceof0.5-1.5casesper100,000individualsandageatdiagnosisaround60(anincreasedprevalenceisnotedinAshkenaziJews).Clinicalmanifestationsdependonthetypeofbloodcellaffectedandmayincludeanemia,pallor,splenomegaly,hypermetabolicstate,petechiae,ecchymosis,bleeding,lymphadenopathy,hepatomegaly,portalhypertension.

        DefectsinJAK2areacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment.

        SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.

        Contains1FERMdomain.

        Contains1proteinkinasedomain.

        Contains1SH2domain....
        MolecularWeight~125kDaObservedUniProtKB/Swiss-ProtO60674(JAK2_HUMAN)listsamassof130,674Da.
        PhysicochemicalInformation
        Dimensions
        MaterialsInformation
        MaterialsInformation
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